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FDAs scrutiny of these substances reflects a legitimate concern about ensuring that compounded products are safe and that clinical claims are substantiated but it also creates very real uncertainty for providers and patients who have relied on these compounds

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They are used in people of all ages who are sick, injured, dehydrated from exercise or heat, or undergoing surgery

The nasal mucosa offers two potential absorption pathways: paracellular transport between epithelial cells, and transcellular transport through cells